Bis-Tos- (2-hydroxyethyl disulfide)
Bis-Tos- (2-hydroxyethyl disulfide) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
[69981-39-1]
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bis-tos-2-hydroxyethyl-disulfide.html
Purity
99.51
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(C)C=C1)(OCCSSCCOS(C2=CC=C(C)C=C2)(=O)=O)=O
Molecular Formula
C18H22O6S4
Molecular Weight
462.62
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Disulfide Cleavable Linker
Available Sizes
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