Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-B7H4/VTCN1 Antibody Picoband® (Dylight488 Conjugate)

Boster Bio Anti-B7H4/VTCN1 Antibody Picoband® catalog # A02821-3. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

V-set domain-containing T-cell activation inhibitor 1 is a protein that in humans is encoded by the VTCN1 gene. It is mapped to 1p13.1-p12. This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms

V-set domain-containing T-cell activation inhibitor 1; B7 homolog 4; B7-H4; B7h.5; Immune costimulatory protein B7-H4; Protein B7S1; T-cell costimulatory molecule B7x; VTCN1; B7H4; UNQ659; PRO1291

Gene Name

V-set domain containing T cell activation inhibitor 1

UniProt

Q7Z7D3

Host

Rabbit

Reactivity

Human,Mouse,Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human B7H4/VTCN1 recombinant protein (Position: T57-A258).

Clonality

Polyclonal

Tissue Specificity

Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.

Applications

ELISA,Flow Cytometry,IF,IHC,ICC,WB

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A02821-3

Product MSDS

https://www.bosterbio.com/msds?sku=A02821-3

Fragment

Rabbit IgG

Applications Notes

Western blot, 0.25-0.5μg/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml<br> Immunocytochemistry/Immunofluorescence, 2μg/ml<br> Flow Cytometry (Fixed), 1-3μg/1x10<sup>6</sup> cells<br> ELISA, 0.1-0.5μg/ml<br>

Subcellular Location

Cell membrane. Single-pass type I membrane protein.

Protein Name

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Anti-C1q antibody
STJ16101437 1 mL

Anti-C1q antibody

Ask
View Details
Active Plasmin/Antiplasmin Complex (PAP)
APA832Hu63-01 10 µg

Active Plasmin/Antiplasmin Complex (PAP)

Ask
View Details
Active Plasmin/Antiplasmin Complex (PAP)
APA832Hu63-02 50 µg

Active Plasmin/Antiplasmin Complex (PAP)

Ask
View Details
Active Plasmin/Antiplasmin Complex (PAP)
APA832Hu63-03 100 µg

Active Plasmin/Antiplasmin Complex (PAP)

Ask
View Details
Active Plasmin/Antiplasmin Complex (PAP)
APA832Hu63-04 200 µg

Active Plasmin/Antiplasmin Complex (PAP)

Ask
View Details
Active Plasmin/Antiplasmin Complex (PAP)
APA832Hu63-05 500 µg

Active Plasmin/Antiplasmin Complex (PAP)

Ask
View Details