PYD-106

PYD-106 is a stereoselective pyrrolidinone (PYD) positive allosteric modulator for GluN2C-containing NMDA receptors. PYD-106 increases opening frequency and open time of single channel currents activated by maximally effective concentrations of agonist but only has modest effects on glutamate and glycine EC50. PYD-106 selectively enhances the responses of diheteromeric GluN1/GluN2C receptors but not triheteromeric GluN1/GluN2A/GluN2C receptors[1].

Product Specifications

CAS Number

[1560894-05-4]

Product Name Alternative

CB-5945; ADL-5945

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pyd-106.html

Purity

98.13

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(OC)C1=CC=C(C(C(C(C)=O)=C2O)N(CCC3=C(C)NC4=C3C=CC=C4)C2=O)C=C1

Molecular Formula

C25H24N2O5

Molecular Weight

432.47

References & Citations

[1]Khatri A, et al. Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator. Mol Pharmacol. 2014;86 (5) :548-560.