Cyclothiazide

Cyclothiazide is a positive allosteric modulator of ionotropic AMPA-type glutamate receptors. Cyclothiazide inhibits GABAA receptors. Cyclothiazide is frequently used to produce a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current. Cyclothiazide can potentiate responses to kainate in hippocampal neurons. Cyclothiazide has effects on glutamatergic neurotransmission. Cyclothiazide also induces epileptiform EEG activity accompanying behavioral seizures[1][2][3][4].

Product Specifications

CAS Number

[2259-96-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor; iGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cyclothiazide.html

Purity

98.78

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=S(C1=C(Cl)C=C(C2=C1)NC(C3C(C4)C=CC4C3)NS2(=O)=O)(N)=O

Molecular Formula

C14H16ClN3O4S2

Molecular Weight

389.88

Precautions

H302, H315, H319, H335

References & Citations

[1]Fucile S, et al. Effects of cyclothiazide on GluR1/AMPA receptors. Proc Natl Acad Sci U S A. 2006;103 (8) :2943-2947. |[2]Patneau, D. K., et al., (1993) . Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate. The Journal of neuroscience: the official journal of the Society for Neuroscience, 13 (8), 3496–3509.|[3]Partin, K. M., et al., (1993) . Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A. Neuron, 11 (6), 1069–1082.|[4]Qi, J., et al., (2006) . Cyclothiazide induces robust epileptiform activity in rat hippocampal neurons both in vitro and in vivo. The Journal of physiology, 571 (Pt 3), 605–618.