PHD-1-IN-1

PHD-1-IN-1 is an orally active and potent HIF prolylhydroxylase domain-1 (PHD-1) inhibitor with an IC50 of 0.034 μM. PHD-1-IN-1 has a unique monodentate binding interaction with the active site Fe2+ ion and induces the formation of an "Arg367-out" pocket[1].

Product Specifications

CAS Number

[2009343-14-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/phd-1-in-1.html

Purity

99.54

Solubility

DMSO : 195 mg/mL (ultrasonic)

Smiles

N#CC1=CC=C(C2=CC=CC3=NC=NN23)C=C1

Molecular Formula

C13H8N4

Molecular Weight

220.23

Precautions

H302, H315, H319

References & Citations

[1]Ahmed S, et al. 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction. J Med Chem. 2017 Jul 13;60 (13) :5663-5672.