TAK-448
TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM[1].
Product Specifications
CAS Number
1234319-68-6
Product Name Alternative
MVT-602
UNSPSC
12352209
Target
Kisspeptin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tak-448.html
Purity
99.90
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(N)[C@H](CC1=CNC2=CC=CC=C12)NC([C@H](CCCNC(NC)=N)NC([C@H](CC(C)C)NC(NNC([C@H](CC3=CC=CC=C3)NC([C@H]([C@H](O)C)NC([C@H](CC(N)=O)NC([C@H]4N(C([C@@H](CC5=CC=C(C=C5)O)NC(C)=O)=O)C[C@H](O)C4)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C58H80N16O14
Molecular Weight
1225.36
References & Citations
[1]1.Nishizawa N, et al. Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp) -Asn-Thr-Phe-azaGly-Leu-Arg (Me) -Trp-NH2 (TAK-448), with Highly PotentTestosterone-Suppressive Activity and Excellent Water Solubility. J Med Chem. 2016 Oct 13;59 (19) :8804-8811.|[2]Ishikawa K, et al. Usefulness of pharmacokinetic/efficacy analysis of an investigational kisspeptin analog, TAK-448, in quantitatively evaluating anti-tumor growth effect in the rat VCaP androgen-sensitiveprostate cancer model. Eur J Pharmacol. 2018 Jun 5;828:126-134.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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