PETCM
PETCM is an activator of caspase-3 and acts as an cytochrome c (cyto c) -dependent manner. PETCM promotes Apaf-1 oligomerization and induces cell apoptosis in HeLa cells[1][2].
Product Specifications
CAS Number
10129-56-3
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Apoptosis; Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/petcm.html
Purity
99.68
Solubility
DMSO : 100 mg/mL (ultrasonic; heat to 40°C)
Smiles
OC(C(Cl)(Cl)Cl)CC1=CC=NC=C1
Molecular Formula
C8H8Cl3NO
Molecular Weight
240.51
Precautions
H315, H319, H320
References & Citations
[1].Jiang X, Kim HE, Shu H, et al. Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science, 2003, 299 (5604) : 223-226.|[2]Nguyen JT, et al. Direct activation of the apoptosis machinery as a mechanism to target cancer cells.Proc Natl Acad Sci U S A. 2003 Jun 24;100 (13) :7533-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3
Available Sizes
Frequently Asked Questions
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