PETCM

PETCM is an activator of caspase-3 and acts as an cytochrome c (cyto c) -dependent manner. PETCM promotes Apaf-1 oligomerization and induces cell apoptosis in HeLa cells[1][2].

Product Specifications

CAS Number

[10129-56-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Apoptosis; Caspase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/petcm.html

Purity

99.68

Solubility

DMSO : 100 mg/mL (ultrasonic; heat to 40°C)

Smiles

OC(C(Cl)(Cl)Cl)CC1=CC=NC=C1

Molecular Formula

C8H8Cl3NO

Molecular Weight

240.51

Precautions

H315, H319, H320

References & Citations

[1].Jiang X, Kim HE, Shu H, et al. Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science, 2003, 299 (5604) : 223-226.|[2]Nguyen JT, et al. Direct activation of the apoptosis machinery as a mechanism to target cancer cells.Proc Natl Acad Sci U S A. 2003 Jun 24;100 (13) :7533-8.