Seltorexant (hydrochloride)
Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R) . Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain[1].
Product Specifications
CAS Number
1293284-49-7
Product Name Alternative
JNJ-42847922 (hydrochloride)
UNSPSC
12352005
Target
Orexin Receptor (OX Receptor)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Endocrinology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/seltorexant-hydrochloride.html
Purity
99.57
Solubility
DMSO : 83.33 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(N1CC(CN(C2=NC(C)=CC(C)=N2)C3)C3C1)C4=C(N5N=CC=N5)C=CC=C4F.[H]Cl
Molecular Formula
C21H23ClFN7O
Molecular Weight
443.91
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
OX2 Receptor
Citation 01
Int J Neuropsychopharmacol. 2025 Aug 1;28 (8) :pyaf047.|Bioorg Chem. 2022 Jun;123:105779.|Int J Neuropsychopharmacol. 2025 Aug 1;28 (8) :pyaf047.
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