Seltorexant (hydrochloride)

Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R) . Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain[1].

Product Specifications

CAS Number

[1293284-49-7]

Product Name Alternative

JNJ-42847922 (hydrochloride)

UNSPSC

12352005

Target

Orexin Receptor (OX Receptor)

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/seltorexant-hydrochloride.html

Purity

99.57

Solubility

DMSO : 83.33 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(N1CC(CN(C2=NC(C)=CC(C)=N2)C3)C3C1)C4=C(N5N=CC=N5)C=CC=C4F.[H]Cl

Molecular Formula

C21H23ClFN7O

Molecular Weight

443.91

References & Citations

[1]Bonaventure P, et al. Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia. J Pharmacol Exp Ther. 2015 Sep;354 (3) :471-82.