Supinoxin
Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase (P-p68) and a potent first-in-class anti-cancer agent. Supinoxin interacts with Y593 phosphorylated-p68 and attenuates the nuclear shuttling of β-catenin. Supinoxin induces cell apoptosis and inhibits growth of TNBC cancer cell lines with IC50s ranging from 10 nM to 20 nM[1][2].
Product Specifications
CAS Number
888478-45-3
Product Name Alternative
RX-5902
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/supinoxin.html
Purity
99.67
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1CCN(C2=CC(OC)=CC(OC)=C2)CC1)NC3=NC4=CC(F)=CC=C4N=C3OC
Molecular Formula
C22H24FN5O4
Molecular Weight
441.46
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
RNF11, ID (RNF11, RING finger protein 11) (MaxLight 750)
RNF11, ID (RNF11, RING finger protein 11) (MaxLight 750)
![Mouse Monoclonal TMEM80 Antibody (OTI3A6) [Dylight 594]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
Mouse Monoclonal TMEM80 Antibody (OTI3A6) [Dylight 594]
Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N), partial
Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N), partial