Sarcosine-d3

Sarcosine-d3 is the deuterium labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].

Product Specifications

CAS Number

[118685-91-9]

Product Name Alternative

N-Methylglycine-d3; Sarcosin-d3

UNSPSC

12352211

Hazard Statement

H302, H312, H332

Target

Endogenous Metabolite; GlyT; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.05

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

O=C(O)CNC([2H])([2H])[2H]

Molecular Formula

C3H4D3NO2

Molecular Weight

92.11

Precautions

H302, H312, H332

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Katarzyna Socała, et al. Effects of sarcosine, a glycine transporter type 1 inhibitor, in two mouse seizure models. Pharmacol Rep. Mar-Apr 2010;62 (2) :392-7.|[3]Mei-Yi Lee, et al. Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials. J Biomed Sci. 2017; 24: 18.