Zoniporide
Product Specifications
UNSPSC Description
Zoniporide (CP-597396) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits 22Na+ uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC50=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC50 of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease[1].
Target Antigen
Na+/H+ Exchanger (NHE)
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/zoniporide.html
Purity
99.89
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
N=C(N)NC(C1=C(C2CC2)N(C3=C4C(N=CC=C4)=CC=C3)N=C1)=O
Molecular Weight
320.35
References & Citations
[1]Marala, et al. "Zoniporide: a potent and highly selective inhibitor of human Na+/H+ exchanger-1." European journal of pharmacology 451.1 (2002): 37-41.Carbohydr Polym. 1 January 2023, 120179.|J Biol Chem. 2021 Sep 3;101166.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-105064/Zoniporide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-105064/Zoniporide-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
241800-98-6
Available Sizes
Curated Selection
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