ML167
ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1, Clk2, Clk3 and Dyrk1A/1B[1].
Product Specifications
CAS Number
[1285702-20-6]
Product Name Alternative
CID44968231; NCGC00188654
UNSPSC
12352005
Hazard Statement
H302
Target
CDK; DYRK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ML167.html
Concentration
10mM
Purity
98.62
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
OCC1=CC=C(C2=CC3=C(NCC4=CC=C(C)O4)N=CN=C3C=C2)O1
Molecular Formula
C19H17N3O3
Molecular Weight
335.36
Precautions
H302
References & Citations
[1]Rosenthal AS, et al. An inhibitor of the Cdc2-like kinase 4 (Clk4) .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK3; CLK; DYRK1
Available Sizes
Curated Selection
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