FKBP12 PROTAC RC32
Product Specifications
Product Name Alternative
RC32
UNSPSC Description
FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology. FKBP12 PROTAC RC32 contains conjugation of Rapamycin (HY-10219) and a ligand for an Cereblon E3 ubiquitin ligase (Pomalidomide; HY-10984)[1].
Target Antigen
FKBP; PROTACs
Type
Reference compound
Related Pathways
Apoptosis;Autophagy;Cell Cycle/DNA Damage;Immunology/Inflammation;PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fkbp12-protac-rc32.html
Purity
98.58
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
C/C([C@@H](OC)C[C@@]([H])(O[C@]1(C(C(N2[C@]([H])3CCCC2)=O)=O)O)CC[C@H]1C)=C\C=C\C=C\[C@@H](C)C[C@@H](C)C([C@H](OC)[C@H](O)/C(C)=C/[C@H](C(C[C@@H]([C@H](C)C[C@]4([H])CC[C@@H](OCCOCC5=CN(CCOCCOCCNC6=CC=CC(C(N7C8C(NC(CC8)=O)=O)=O)=C6C7=O)N=N5)[C@H](OC)C4)OC3=O)=O)C)=O
Molecular Weight
1426.69
References & Citations
[1]A chemical approach for global protein knockdown from mice to non-human primates. Cell Discov. 2019 Feb 5;5:10.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-130835/FKBP12-PROTAC-RC32-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-130835/FKBP12-PROTAC-RC32-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2375555-66-9
Available Sizes
Curated Selection
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