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FKBP12 PROTAC RC32

FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology. FKBP12 PROTAC RC32 contains conjugation of Rapamycin (HY-10219) and a ligand for an Cereblon E3 ubiquitin ligase (Pomalidomide; HY-10984) [1].

Product Specifications

CAS Number

[2375555-66-9]

Product Name Alternative

RC32

UNSPSC

12352005

Target

FKBP; PROTACs

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fkbp12-protac-rc32.html

Purity

98.02

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

C/C([C@@H](OC)C[C@@]([H])(O[C@]1(C(C(N2[C@]([H])3CCCC2)=O)=O)O)CC[C@H]1C)=C\C=C\C=C\[C@@H](C)C[C@@H](C)C([C@H](OC)[C@H](O)/C(C)=C/[C@H](C(C[C@@H]([C@H](C)C[C@]4([H])CC[C@@H](OCCOCC5=CN(CCOCCOCCNC6=CC=CC(C(N7C8C(NC(CC8)=O)=O)=O)=C6C7=O)N=N5)[C@H](OC)C4)OC3=O)=O)C)=O

Molecular Formula

C75H107N7O20

Molecular Weight

1426.69

References & Citations

[1]A chemical approach for global protein knockdown from mice to non-human primates. Cell Discov. 2019 Feb 5;5:10.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cereblon; FKBP12

Available Sizes

Curated Selection

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