STING agonist-8 (dihydrochloride)

STING agonist-8 dihydrochloride (compound 5-AB) is a potent STING agonist with an EC50 of 27 nM in THP1-Dual KI-hSTING-R232 cells[1].

STING

Reference compound

Immunology/Inflammation

COVID-19-immunoregulation

Inflammation/Immunology

https://www.medchemexpress.com/sting-agonist-8-dihydrochloride.html

DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C)

O=C(C1=CC(C)=NN1CC)NC2=NC3=CC(C(N)=O)=CN=C3N2C/C=C/CN4C5=C(OCCCC6CNC6)C=C(C(N)=O)C=C5C7=CN=C(C8=CC(C)=NN8CC)N=C74.[H]Cl.[H]Cl

871.82

[1]Heterocyclic compounds as sting modulators. WO2021239068A1.

Blue Ice

http://file.medchemexpress.com/batch_PDF/HY-144168A/STING-agonist-8-dihydrochloride-DataSheet-MedChemExpress.pdf

http://file.medchemexpress.com/batch_PDF/HY-144168A/

No Development Reported