ML347

ML347 (LDN193719) is a highly selective ALK1/ALK2 inhibitor. ML347 has IC50 values of 46 and 32 nM against ALK1 and ALK2, respectively, >300-fold selective over ALK3. ML347 block the phosphorylation of Smad1/5 by TGF-β1[1][2].

Product Specifications

CAS Number

[1062368-49-3]

Product Name Alternative

LDN 193719

UNSPSC

12352005

Hazard Statement

H302, H319, H332, H372, H400

Target

TGF-β Receptor

Type

Reference compound

Related Pathways

TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ML347.html

Purity

99.94

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

COC1=CC=C(C2=CN3C(N=C2)=C(C4=C5C=CC=NC5=CC=C4)C=N3)C=C1

Molecular Formula

C22H16N4O

Molecular Weight

352.39

Precautions

H302, H319, H332, H372, H400

References & Citations

[1]Zhang H, et al. Dual roles of TGF-β signaling in the regulation of dental epithelial cell proliferation. J Mol Histol. 2021 Feb;52 (1) :77-86. |[2]Engers DW, et al. Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23 (11) :3248-52.