L-Cysteine (hydrochloride hydrate)

L-Cysteine hydrochloride hydrate is an orally active and essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride hydrate regulates CBS/H2S pathway, inhibits NF-κB activation and insulin and ghrelin secretion. L-Cysteine hydrochloride hydrate reduces blood sugar, vascular inflammation markers and appetite. L-Cysteine hydrochloride hydrate induces kidney damage. L-Cysteine hydrochloride hydrate can be used in the study of neurological diseases and diabetes[1][2][3][4][5][6][7][8][9].

Product Specifications

CAS Number

[7048-04-6]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Insulin Receptor; NF-κB

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/l-cysteine-hydrochloride-hydrate.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N[C@@H](CS)C(O)=O.[H]Cl.[H]O[H]

Molecular Formula

C3H10ClNO3S

Molecular Weight

175.63

Precautions

H302, H315, H319, H335

References & Citations

[1]McGavigan AK, et al. L-cysteine suppresses ghrelin and reduces appetite in rodents and humans. Int J Obes (Lond) . 2015 Mar;39 (3) :447-55.|[2]Qiu M, et al. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB1 synthesis by disrupting cell structure and antioxidant system balance. J Hazard Mater. 2023 Oct 5;459:132218.|[3]Wang Z, et al. L-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/H₂S pathway. Neuroscience. 2013 May 1;237:106-17.|[4]Kaneko Y, et al. L-cysteine inhibits insulin release from the pancreatic beta-cell: possible involvement of metabolic production of hydrogen sulfide, a novel gasotransmitter. Diabetes. 2006 May;55 (5) :1391-7.|[5]Shibui Y, et al. Comparisons of l-cysteine and d-cysteine toxicity in 4-week repeated-dose toxicity studies of rats receiving daily oral administration. J Toxicol Pathol. 2017 Jul;30 (3) :217-229.|[6]Mahmoud YI, et al. Effects of L-cysteine on lead acetate induced neurotoxicity in albino mice. Biotech Histochem. 2016 Jul;91 (5) :327-32.|[7]McGavigan AK, et al. L-cysteine suppresses ghrelin and reduces appetite in rodents and humans. Int J Obes (Lond) . 2015 Mar;39 (3) :447-55.|[8]Jain SK, et al. L-cysteine supplementation lowers blood glucose, glycated hemoglobin, CRP, MCP-1, and oxidative stress and inhibits NF-kappaB activation in the livers of Zucker diabetic rats. Free Radic Biol Med. 2009 Jun 15;46 (12) :1633-8.|[9]Jain S K, et al. L-Cysteine supplementation lowers blood glucose, glycated hemoglobin, CRP, MCP-1, and oxidative stress and inhibits NF-κB activation in the livers of Zucker diabetic rats. Free Radical Biology and Medicine, 2009, 46 (12) : 1633-1638.