L-Leucine-d1
Product Specifications
UNSPSC Description
L-Leucine-d is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
Target Antigen
Endogenous Metabolite; mTOR
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease;PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Solubility
10 mM in DMSO
Smiles
CC(C)C[C@@](N)([2H])C(O)=O
Molecular Weight
132.18
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857.|[3]Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77.|[4]Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
CAS Number
89836-93-1
Available Sizes
Curated Selection
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