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LP44 (hydrochloride)

LP44 (hydrochloride) is a selective 5-HT7 agonist with Ki of 0.22 nM. LP44 (hydrochloride) induces hypothermic effect in a dose-dependent manner by intracerebroventricular injection. LP44 (hydrochloride) not causes considerable hypothermic response by intraperitoneal administration[1].

Product Specifications

CAS Number

[824958-12-5]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/lp44-hydrochloride.html

Purity

98.12

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CCCCCN1CCN(C(C=CC=C2)=C2SC)CC1)NC3C4=CC=CC=C4CCC3.Cl

Molecular Formula

C27H38ClN3OS

Molecular Weight

488.13

References & Citations

[1]Naumenko VS, et al. On the role of brain 5-HT7 receptor in the mechanism of hypothermia: comparison with hypothermia mediated via 5-HT1A and 5-HT3 receptor. Neuropharmacology. 2011 Dec;61 (8) :1360-5.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT7 Receptor

Available Sizes

Curated Selection

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