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Anti-POLE2 Antibody Picoband®, Cy3 Conjugate

Boster Bio Anti-POLE2 Antibody Picoband® catalog # A09182-2. Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

DNA polymerase epsilon subunit 2 is an enzyme that in humans is encoded by the POLE2 gene. DNA polymerase epsilon, which is involved in DNA repair and replication, is composed of a large catalytic subunit and a small accessory subunit. The protein encoded by this gene represents the small subunit (B). Defects in this gene have been linked to colorectal cancer and to combined immunodeficiency.

Gene Name

POLE2

Gene ID

5427

UniProt

P56282

Host

Rabbit

Reactivity

Human,Mouse,Rat

Immunogen

E.coli-derived human POLE2 recombinant protein (Position: E46-K483). Human POLE2 shares 99.1% amino acid (aa) sequence identity with mouse POLE2.

Clonality

Polyclonal

Applications

WB,Flow Cytometry,ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Components

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

References & Citations

1. Frugoni, F., Dobbs, K., Felgentreff, K., Aldhekri, H., Al Saud, B. K., Arnaout, R., Ali, A. A., Abhyankar, A., Alroqi, F., Giliani, S., Ojeda, M. M., Tsitsikov, E., Pai, S.-Y., Casanova, J. L., Notarangelo, L. D., Manis, J. P. A novel mutation in the POLE2 gene causing combined immunodeficiency. J. Allergy Clin. Immun. 137: 635-638, 2016. 2. Li, Y., Asahara, H., Patel, V. S., Zhou, S., Linn, S. Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon. J. Biol. Chem. 272: 32337-32344, 1997. 3. Stumpf, A. M. Personal Communication. Baltimore, Md. 03/26/2021.

Storage Conditions

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A09182-2

Product MSDS

https://www.bosterbio.com/msds?sku=A09182-2

Applications Notes

Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat<br> Flow Cytometry (Fixed), 1-3 μg/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 μg/ml, -<br>

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