Anti-Glutaredoxin 1/GLRX Antibody Picoband®, Cy3 Conjugate

Glutaredoxin-1 is a protein that in humans is encoded by the GLRX gene. This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified.

Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.

1. Padilla, C. A., Bajalica, S., Lagercrantz, J., Holmgren, A. The gene for human glutaredoxin (GLRX) is localized to human chromosome 5q14. Genomics 32: 455-457, 1996. 2. Padilla, C. A., Martinez-Galisteo, E., Barcena, J. A., Spyrou, G., Holmgren, A. Purification from placenta, amino acid sequence, structure comparisons and cDNA cloning of human glutaredoxin. Europ. J. Biochem. 227: 27-34, 1995. 3. Raghavachari, N., Krysan, K., Xing K., Lou, M. F. Regulation of thioltransferase expression in human lens epithelial cells. Invest. Ophthal. Vis. Sci. 42: 1002-1008, 2001.

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Western blot, 0.25-0.5 μg/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human<br> Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human<br> ELISA, 0.1-0.5 μg/ml, -<br>