Anti-Arsb Antibody Picoband®, Cy3 Conjugate

Boster Bio Anti-Arsb Antibody Picoband® catalog # A01609-3. Tested in WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene

Synonyms

Ras-related protein Rab-27A; Rab-27; GTP-binding protein Ram; RAB27A; RAB27

Gene Name

RAB27A, member RAS oncogene family

Gene ID

11881

UniProt

P50429

Host

Rabbit

Reactivity

Mouse,Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of mouse Arsb, which shares 88.2% and 94.1% amino acid (aa) sequence identity with human and rat Arsb, respectively.

Clonality

Polyclonal

Tissue Specificity

Found in all the examined tissues except in brain. Low expression was found in thymus, kidney, muscle and placenta. Detected in melanocytes, and in most tumor cell lines examined. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.

Applications

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.

Components

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

References & Citations

1. Crawley, A. C., Brooks, D. A., Muller, V. J., Petersen, B. A., Isaac, E. L., Bielicki, J., King, B. M., Boulter, C. D., Moore, A. J., Fazzalari, N. L., Anson, D. S., Byers, S., Hopwood, J. J. Enzyme replacement therapy in a feline model of Maroteaux-Lamy syndrome. J. Clin. Invest. 97: 1864-1873, 1996. 2. Crawley, A. C., Niedzielski, K. H., Isaac, E. L., Davey, R. C. A., Byers, S., Hopwood, J. J. Enzyme replacement therapy from birth in a feline model of mucopolysaccharidosis type VI. J. Clin. Invest. 99: 651-662, 1997. 3. Crawley, A. C., Yogalingam, G., Muller, V. J., Hopwood, J. J. Two mutations within a feline mucopolysaccharidosis type VI colony cause three different clinical phenotypes. J. Clin. Invest. 101: 109-119, 1998.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.