Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-DKK2 Antibody Picoband® (Cy3 Conjugate)

Boster Bio Anti-DKK2 Antibody Picoband® catalog # PB9551. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Dickkopf-related protein 2 is a protein that in humans is encoded by the DKK2 gene. This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).

Synonyms

Dickkopf-related protein 2;Dickkopf-2;Dkk-2;hDkk-2;DKK2;UNQ682/PRO1316;

Gene Name

Dickkopf-related protein 2

UniProt

Q9UBU2

Host

Rabbit

Reactivity

Human,Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human DKK2 recombinant protein (Position: K34-I259). Human DKK2 shares 96% amino acid (aa) sequence identity with mouse DKK2.

Clonality

Polyclonal

Tissue Specificity

Expressed in heart, brain, skeletal muscle and lung.

Applications

WB

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). .

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=PB9551

Product MSDS

https://www.bosterbio.com/msds?sku=PB9551

Fragment

Rabbit IgG

Applications Notes

Western blot, 0.1-0.5μg/ml, Human, Rat<br>

Subcellular Location

Secreted.

Sequence Similarities

Belongs to the DAXX family.

Protein Name

Dickkopf-related protein 2

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Connexin 37 Polyclonal Antibody
UB-GEN-16407 100 ul

Connexin 37 Polyclonal Antibody

Ask
View Details
Human BRINP1 knockout cell line
ABC-KH1563 1 Vial

Human BRINP1 knockout cell line

Ask
View Details
SUV3 rabbit pAb
E28PT7651 100μl

SUV3 rabbit pAb

Ask
View Details
Mouse Monoclonal Albumin Antibody (188835) [CoraFluor 1]
FAB1455CL1 0.1 mL

Mouse Monoclonal Albumin Antibody (188835) [CoraFluor 1]

Ask
View Details