Anti-Bcl-2-related protein A1 Bcl2A1 Antibody Picoband® (Biotine Conjugate)

Bcl-2-related protein A1 (BCL2A1), is the human homolog of the murine A1, and maps to chromosome 15q24.3. The BCL2A1 gene has also been referred to as BCL2L5, BFL1, and GRS. Bfl-1 protein suppresses apoptosis induced by the p53 tumor suppressor protein in a manner similar to other Bcl-2 family members such as Bcl-2, Bcl-xL and EBV-BHRF1. In addition, the bfl-I gene cooperates efficiently with the Ela oncogene in transformation of primary rodent epithelial cells. The human bfl-1 gene may play an important role in carcinogenesis.

Bcl-2-related protein A1;Bcl-2-like protein 5;Bcl2-L-5;Hemopoietic-specific early response protein;Protein BFL-1;Protein GRS;BCL2A1;BCL2L5, BFL1, GRS, HBPA1;

Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies.

Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity). .

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.