Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-HSD11B1 Antibody Picoband® (Biotine Conjugate)

Boster Bio Anti-HSD11B1 Antibody catalog # PA1372-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

11beta-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers. Tannin et al. (1991) localized the HSD11B1 gene to chromosome 1. The localization was confirmed by isolating the gene from a chromosome 1-specific library using the cDNA as a probe. Schutte et al. (2000) mapped the HSD11B1 gene to 1q32-q41.

Synonyms

Corticosteroid 11-beta-dehydrogenase isozyme 1;1.1.1.146;11-beta-hydroxysteroid dehydrogenase 1;11-DH;11-beta-HSD1;Short chain dehydrogenase/reductase family 26C member 1;HSD11B1;HSD11, HSD11L, SDR26C1;

Gene Name

Corticosteroid 11-beta-dehydrogenase isozyme 1

UniProt

P28845

Host

Rabbit

Reactivity

Human,Mouse,Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human HSD11B1, different from the related mouse sequence by two amino acids, and from the related rat sequence by four amino acids.

Clonality

Polyclonal

Tissue Specificity

Widely expressed. Highest expression in liver.

Applications

IHC,WB

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one ion, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity). .

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=PA1372-1

Product MSDS

https://www.bosterbio.com/msds?sku=PA1372-1

Fragment

Rabbit IgG

Applications Notes

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, Mouse, By Heat<br>Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse<br>

Subcellular Location

Endoplasmic reticulum membrane ; Single-pass type II membrane protein .

Sequence Similarities

Belongs to the connexin family. Beta-type (group I) subfamily.

Protein Name

Corticosteroid 11-beta-dehydrogenase isozyme 1

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

TET3 Mouse Monoclonal Antibody [Clone ID: LBI11E11]
AMM16236VCF 100 µg

TET3 Mouse Monoclonal Antibody [Clone ID: LBI11E11]

Ask
View Details
MIRacle™ mmu-miR-652-3p miRNA Agomir/Antagomir
AM3463 33 µg

MIRacle™ mmu-miR-652-3p miRNA Agomir/Antagomir

Ask
View Details
ATP11B ORF Vector (Human) (pORF)
12661012 1.0 µg DNA

ATP11B ORF Vector (Human) (pORF)

Ask
View Details
Genorise® Biotinylated Rat CRP Polyclonal antibody
GR139017 50 mg

Genorise® Biotinylated Rat CRP Polyclonal antibody

Ask
View Details
TNFAIP1 Human qPCR Template Standard (NM_021137)
HK207482 1 Kit

TNFAIP1 Human qPCR Template Standard (NM_021137)

Ask
View Details