Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-ADRM1/ARM-1 Antibody Picoband® (Biotine Conjugate)

Boster Bio Anti-ADRM1/ARM-1 Antibody Picoband® catalog # A04010-2. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Proteasomal ubiquitin receptor ADRM1 is a protein that in humans is encoded by the ADRM1 gene. This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an in effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants.

Synonyms

Ran-specific GTPase-activating protein;Ran-binding protein 1;RanBP1;RANBP1;

Gene Name

Ran-specific GTPase-activating protein

UniProt

Q16186

Host

Rabbit

Reactivity

Human,Mouse,Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human ADRM1/ARM-1 recombinant protein (Position: S15-K390).

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.

Applications

WB,IHC,ICC,IF,Flow Cytometry,ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.

Storage Conditions

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A04010-2

Product MSDS

https://www.bosterbio.com/msds?sku=A04010-2

Fragment

Rabbit IgG

Applications Notes

Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Human, Mouse, Rat<br> Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human<br> Flow Cytometry (Fixed), 1-3 μg/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 μg/ml, -<br>

Subcellular Location

Cytoskeleton. Nucleus. Cell cortex. Bleb.

Protein Name

Ran-specific GTPase-activating protein

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

C5orf47 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
14584111 3 x 1.0 µg

C5orf47 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

Ask
View Details
Human Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) Protein
abx650629-01 10 µg

Human Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) Protein

Ask
View Details
Human Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) Protein
abx650629-02 50 µg

Human Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) Protein

Ask
View Details
Human Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) Protein
abx650629-03 100 µg

Human Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) Protein

Ask
View Details
Human Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) Protein
abx650629-04 200 µg

Human Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) Protein

Ask
View Details
Human Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) Protein
abx650629-05 500 µg

Human Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) Protein

Ask
View Details