Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-IGF1 Antibody (Biotine Conjugate)

Boster Bio <a href="https://www.bosterbio.com/anti-igf-1-antibody-pa1374-boster.html" style="color:#EA8D28">Anti-IGF1 Antibody</a> Picoband&reg; catalog # A00148. Tested in ELISA, Flow Cytometry, IHC applications. This antibody reacts with Human.

Product Specifications

Background

Insulin-like growth factor 1 (IGF-1) also known as somatomedin C or mechano growth factor is a protein that in humans is encoded by the IGF1 gene. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons.Justice et al. (1990) placed the mouse IGF1 gene on chromosome 10.

Synonyms

Angiogenin;3.1.27.-;Ribonuclease 5;RNase 5;ANG;RNASE5;

Gene Name

Angiogenin

UniProt

P05019

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human IGF1 recombinant protein (Position: P50-A118).

Clonality

Polyclonal

Tissue Specificity

Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons. .

Applications

ELISA,Flow Cytometry,IHC

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. .

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A00148

Product MSDS

https://www.bosterbio.com/msds?sku=A00148

Fragment

Rabbit IgG

Applications Notes

Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Human<br> Flow Cytometry (Fixed), 1-3μg/1x10<sup>6</sup> cells, Human<br> ELISA (Cap), 1-5μg/ml, Human<br>

Subcellular Location

Nucleus . Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus, nucleolus. Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA.

Protein Name

Angiogenin

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Medium for Rat Epididymis Fibroblasts (EF)
abx710296-01 100 mL

Medium for Rat Epididymis Fibroblasts (EF)

Ask
View Details
Medium for Rat Epididymis Fibroblasts (EF)
abx710296-02 500 mL

Medium for Rat Epididymis Fibroblasts (EF)

Ask
View Details
Medium for Rat Epididymis Fibroblasts (EF)
abx710296-03 1 L

Medium for Rat Epididymis Fibroblasts (EF)

Ask
View Details
Human Cardiac myosin-light chains 1, CMLC-1 ELISA Kit
E01C2351-01 48 Well

Human Cardiac myosin-light chains 1, CMLC-1 ELISA Kit

Ask
View Details
Human Cardiac myosin-light chains 1, CMLC-1 ELISA Kit
E01C2351-02 96 Well

Human Cardiac myosin-light chains 1, CMLC-1 ELISA Kit

Ask
View Details
Goat Cytochrome P450 7A1 ELISA Kit
E06C0375-01 48 Well

Goat Cytochrome P450 7A1 ELISA Kit

Ask
View Details