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Anti-LOC134147/CMBL Antibody Picoband® (Biotine Conjugate)

Selected Variant

A04921-Biotin

Size: 100 µg/Vial

Boster Bio Anti-LOC134147/CMBL Antibody Picoband® catalog # A04921. Tested in Flow Cytometry, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

CMBL is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom.

Synonyms

Meiotic recombination protein REC8 homolog; Cohesin Rec8p; REC8; REC8L1

Gene Name

REC8 meiotic recombination protein

UniProt

Q8R1G2

Host

Rabbit

Reactivity

Mouse,Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of mouse LOC134147/CMBL, which shares 88.2% and 94.1% amino acid (aa) sequence identity with human and rat LOC134147/CMBL, respectively.

Clonality

Polyclonal

Tissue Specificity

Expressed in testis and thymus. Expressed in the B-cell lines WI-L2-NS and Namalwa.

Applications

WB,Flow Cytometry

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Applications Notes

Western blot, 0.25-0.5μg/ml, Mouse, Rat<br> Flow Cytometry (Fixed), 1-3μg/1x10<sup>6</sup> cells, Mouse<br>

Subcellular Location

Nucleus. Chromosome. Centromere.

Protein Name

Vesicular acetylcholine transporter

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