Ioxaglic acid

Ioxaglic acid (P-286) is negatively charged contrast agent, is useful as an inverse indicator for glycosaminoglycan (GAG) used in computed tomography (CT) . Ioxaglic acid can be used for imaging of human osteoarthritic cartilage via quantitative assessment of glycosaminoglycan content[1][2].

Product Specifications

CAS Number

[59017-64-0]

Product Name Alternative

P-286

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Biochemical Assay Reagents

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ioxaglic-acid.html

Solubility

10 mM in DMSO

Smiles

IC(C(C(NCCO)=O)=C(I)C(C(O)=O)=C1I)=C1NC(CNC(C2=C(C(N(C)C(C)=O)=C(I)C(C(NC)=O)=C2I)I)=O)=O

Molecular Formula

C24H21I6N5O8

Molecular Weight

1268.88

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Gonsette RE, et, al. New contrast media in cerebral angiography: animal experiments and preliminary clinical studies. Invest Radiol. Nov-Dec 1980;15 (6 Suppl) :S270-4.|[2]Baer K, et, al. Spectral CT imaging of human osteoarthritic cartilage via quantitative assessment of glycosaminoglycan content using multiple contrast agents. APL Bioeng. 2021 Apr 1;5 (2) :026101.