NP-313

NP-313 is a potent antithrombotic agent that inhibits platelet aggregation and activation. NP-313 has dual inhibition of thromboxane A 2 synthesis and selective inhibition of SOCC-mediated Ca2+ inward flow[1].

Product Specifications

CAS Number

[5397-78-4]

UNSPSC

12352005

Hazard Statement

H301

Target

Thrombin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/np-313.html

Purity

99.58

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CC(NC(C1=O)=C(Cl)C(C2=C1C=CC=C2)=O)=O

Molecular Formula

C12H8ClNO3

Molecular Weight

249.65

Precautions

H301

References & Citations

[1]Heng-Lan Kuo, et al. NP-313, 2-acetylamino-3-chloro-1,4-naphthoquinone, a novel antithrombotic agent with dual inhibition of thromboxane A (2) synthesis and calcium entry. Br J Pharmacol. 2011 Apr;162 (8) :1871-83.