NP-313
NP-313 is a potent antithrombotic agent that inhibits platelet aggregation and activation. NP-313 has dual inhibition of thromboxane A 2 synthesis and selective inhibition of SOCC-mediated Ca2+ inward flow[1].
Product Specifications
CAS Number
5397-78-4
UNSPSC
12352005
Hazard Statement
H301
Target
Thrombin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/np-313.html
Purity
99.58
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC(NC(C1=O)=C(Cl)C(C2=C1C=CC=C2)=O)=O
Molecular Formula
C12H8ClNO3
Molecular Weight
249.65
Precautions
H301
References & Citations
[1]Heng-Lan Kuo, et al. NP-313, 2-acetylamino-3-chloro-1,4-naphthoquinone, a novel antithrombotic agent with dual inhibition of thromboxane A (2) synthesis and calcium entry. Br J Pharmacol. 2011 Apr;162 (8) :1871-83.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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