AR453588
AR453588 is a potent and orally bioavailable anti-diabetic glucokinase activator, with an EC50 of 42 nM. AR453588 shows anti-hyperglycemic activity[1].
Product Specifications
CAS Number
1065609-00-8
UNSPSC
12352005
Target
Glucokinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ar453588.html
Concentration
10mM
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(N1CCC(C2=NSC(NC3=NC=C(SC4=NC=CC=C4)C=C3OC5=CC=CN=C5C)=N2)CC1)=O
Molecular Formula
C25H25N7O2S2
Molecular Weight
519.64
References & Citations
[1]Hinklin RJ, et al. Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator. Bioorg Med Chem. 2020 Jan 1;28 (1) :115232.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![GFPT1 Recombinant Rabbit Monoclonal Antibody [JE43-68]](https://cdn.genprice.uk/products/992/68dd1c8a061270361ea81373/imageurl/ha721554.webp)
HA721554 100 µL
GFPT1 Recombinant Rabbit Monoclonal Antibody [JE43-68]
Sign In for Pricing
View Details 
