(±) -Stylopine

(±) -Stylopine (Tetrahydrocoptisine) is an alkaloid compound. (±) -Stylopine can be isolated from the tubers of the plant Corydalis. (±) -Stylopine inhibits TNF-α, IL-6, and NO production, and attenuates phosphorylation of p38 MAPK, ERK1/2. (±) -Stylopine inhibits NF-κB expression. (±) -Stylopine exhibits anti-inflammatory activity. (±) -Stylopine has protective effects against foot edema, gastric ulcers, anxiety, depression, and acute lung injury[1][2][3][4].

Product Specifications

CAS Number

[4312-32-7]

Product Name Alternative

Tetrahydrocoptisine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Interleukin Related; NF-κB; NO Synthase; p38 MAPK; PERK

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Tetrahydrocoptisine.html

Purity

99.86

Solubility

Acetone : 1 mg/mL (ultrasonic) |DMF : 4 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C1(C(CCN2CC3=C4OCOC4=CC=C3CC21)=C5)=CC6=C5OCO6

Molecular Formula

C19H17NO4

Molecular Weight

323.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Li W, et al. Anti-inflammatory effect of tetrahydrocoptisine from Corydalis impatiens is a function of possible inhibition of TNF-α, IL-6 and NO production in lipopolysaccharide-stimulated peritoneal macrophages through inhibiting NF-κB activation and MAPK pathway. Eur J Pharmacol. 2013 Sep 5;715 (1-3) :62-71.|[2]Li W, et al. Protective effect of tetrahydrocoptisine against ethanol-induced gastric ulcer in mice. Toxicol Appl Pharmacol. 2013 Oct 1;272 (1) :21-9.|[3]Khatun A, et al. In-Silico and In-Vivo Characterization of Anti-Neuro inflammatory potential of Tetrahydrocoptisine by using LPS-Induced model in mice. Neuroscience. 2025 Jan 26;565:232-246. |[4]Li W, et al. Tetrahydrocoptisine protects rats from LPS-induced acute lung injury. Inflammation. 2014 Dec;37 (6) :2106-15.