Nevadensin

Nevadensin (Lysionotin), a natural flavonoid, is a selective human carboxylesterase 1 (hCE1) inhibitor with an IC50 of 2.64 μM. Nevadensin is more selective for hCE1 than hCE2 (IC50 of 132.8 μM) . Nevadensin can induce apoptosis and DNA damage in cancer cells. Nevadensin has a variety of pharmacological effects such as anti-inflammatory, anti-tumour, anti-hypertensive, anti-tubercular, antitussive, antioxidant and anti-microbial activities[1][2][3][4][5].

Product Specifications

CAS Number

[10176-66-6]

Product Name Alternative

Lysionotin

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Bacterial; Carboxylesterase (CES) ; DNA/RNA Synthesis

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Infection; Endocrinology; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nevadensin.html

Purity

99.93

Solubility

DMSO : 14.71 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC=C(OC)C=C2)OC3=C(OC)C(O)=C(OC)C(O)=C13

Molecular Formula

C18H16O7

Molecular Weight

344.32

Precautions

H315, H319, H335

References & Citations

[1]Ya-Qiao Wang, et al. Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1. Int J Biol Macromol. 2018 Dec;120 (Pt B) :1944-1954.|[2]Suksamrarn A, et al. Antimycobacterial and antioxidant flavones from Limnophila geoffrayi. Arch Pharm Res. 2003 Oct;26 (10) :816-20.|[3]Müller L, et al. Topoisomerase poisoning by the flavonoid nevadensin triggers DNA damage and apoptosis in human colon carcinoma HT29 cells. Arch Toxicol. 2021 Dec;95 (12) :3787-3802. |[4]Shi H, et al. Activating the Hippo pathway by nevadensin overcomes Yap-drived resistance to sorafenib in hepatocellular carcinoma. Discov Oncol. 2023 May 27;14 (1) :83. |[5]Zhang YF , et al. Nevadensin relieves food allergic responses and passive cutaneous anaphylaxis in mice through inhibiting the expression of c-Kit receptors. Food Funct. 2020 Dec 1;11 (12) :10375-10385.