Kavain

Kavain is a class of kavalactone isolated from Piper methysticum, which has anxiolytic properties in animals and humans. Kavain positively modulated γ-Aminobutyric acid type A (GABAA) receptor[1].

Product Specifications

CAS Number

[3155-48-4]

UNSPSC

12352005

Hazard Statement

H302

Target

GABA Receptor

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/kavain.html

Purity

99.89

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C=C(OC)CC(/C=C/C2=CC=CC=C2)O1

Molecular Formula

C14H14O3

Molecular Weight

230.26

Precautions

H302

References & Citations

[1]Chua HC, et al. Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism. PLoS One. 2016 Jun 22;11 (6) :e0157700.