TCS 21311

TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibits PKCα, PKCθ, and GSK3β with IC50s of 13, 68, and 3 nM, respectively[1].

Product Specifications

CAS Number

[1260181-14-3]

Product Name Alternative

NIBR3049

UNSPSC

12352005

Target

GSK-3; JAK; PKC

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tcs-21311.html

Purity

99.49

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C(C1=CC(N2CCN(C(C(C)(O)C)=O)CC2)=CC=C1C(F)(F)F)=C3C4=CNC5=C4C=CC=C5)NC3=O

Molecular Formula

C27H25F3N4O4

Molecular Weight

526.51

References & Citations

[1]Thoma G, et al. Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family.J Med Chem. 2011 Jan 13;54 (1) :284-8.