HIF-IN-1
HIF-IN-1 (Compound 3c) is a hypoxia-inducible factor (HIF) -1 inhibitor. HIF-IN-1 suppresses HIF-1α protein accumulation without affecting the levels of HIF-1α mRNA. HIF-IN-1 shows no obvious cytotoxicity[1].
Product Specifications
CAS Number
2393928-76-0
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hif-in-1.html
Purity
98.00
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C2C=NN1C3=CC=C(C)C=C3)C4=C2C=CC=C4
Molecular Formula
C17H12N2O
Molecular Weight
260.29
References & Citations
[1]Fuse S, et al. Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF) -1 transcriptional activity. Bioorg Med Chem. 2020 Jan 1;28 (1) :115207.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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