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HIF-IN-1

HIF-IN-1 (Compound 3c) is a hypoxia-inducible factor (HIF) -1 inhibitor. HIF-IN-1 suppresses HIF-1α protein accumulation without affecting the levels of HIF-1α mRNA. HIF-IN-1 shows no obvious cytotoxicity[1].

Product Specifications

CAS Number

2393928-76-0

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hif-in-1.html

Purity

98.00

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C2C=NN1C3=CC=C(C)C=C3)C4=C2C=CC=C4

Molecular Formula

C17H12N2O

Molecular Weight

260.29

References & Citations

[1]Fuse S, et al. Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF) -1 transcriptional activity. Bioorg Med Chem. 2020 Jan 1;28 (1) :115207.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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