GNE7599
GNE7599 is a high-affinity and orally active von Hippel-Lindau (VHL) ligand with a Kd of 540 pM. GNE7599 can be connected to the ligand for protein by a linker to form PROTACs[1].
Product Specifications
CAS Number
2771069-76-0
UNSPSC
12352005
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gne7599.html
Purity
99.19
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C([C@@H](N1N=NC(C2CC2)=C1)C(C)(C)C)N3C[C@H](O)C[C@H]3C(N[C@H]4CCCCC5=C4C=CC(C6=C(C)N=CS6)=C5)=O
Molecular Formula
C31H40N6O3S
Molecular Weight
576.75
References & Citations
[1]Hao Wu, et al. Potency-Enhanced Peptidomimetic VHL Ligands with Improved Oral Bioavailability. J Med Chem. 2024 Jun 13;67 (11) :8585-8608.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
Frequently Asked Questions
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