5,7-Dihydroxychromone

5,7-Dihydroxychromone, the extract of Cudrania tricuspidata, activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA) -induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated caspase-3 and caspase-9 and cleaved PARP in 6-OHDA-induced SH-SY5Y cells[1].

Product Specifications

CAS Number

[31721-94-5]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Arenavirus; Caspase; Keap1-Nrf2; PARP

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5-7-dihydroxychromone.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=COC2=CC(O)=CC(O)=C12

Molecular Formula

C9H6O4

Molecular Weight

178.14

Precautions

H315, H319

References & Citations

[1]Kim DW, et al. Neuroprotection against 6-OHDA-induced oxidative stress and apoptosis in SH-SY5Y cells by 5,7-Dihydroxychromone: Activation of the Nrf2/ARE pathway. Life Sci. 2015 Jun 1;130:25-30.