APS-2-79
APS-2-79 is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling[1].
Product Specifications
CAS Number
[2002381-25-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MEK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/APS-2-79.html
Purity
99.38
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
CC1=CC(OC2=CC=CC=C2)=CC=C1NC3=NC=NC4=CC(OC)=C(OC)C=C43
Molecular Formula
C23H21N3O3
Molecular Weight
387.43
Precautions
H302, H315, H319, H335
References & Citations
[1]Dhawan NS, et al. Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature. 2016 Aug 24;537 (7618) :112-116.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MEK1
Available Sizes
Curated Selection
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