MS9449

MS9449 is a potent PROTAC EGFR degrader with Kds of 17 nM and 10 nM for EGFR WT and EGFR L858R, respectively. MS9449 effectively induces degradation of mutant EGFRs through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9449 potently inhibits the proliferation of NSCLC cells. MS9449 can be used for researching anticancer[1].

Product Specifications

CAS Number

[2772612-96-9]

UNSPSC

12352005

Target

EGFR; PROTACs

Type

Reference compound

Related Pathways

JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ms9449.html

Purity

98.95

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C([C@H]1N(C([C@@H](C2=CC(C)=NO2)C(C)C)=O)C[C@H](O)C1)N[C@H](C3=CC=C(C4=C(C)N=CS4)C=C3)CC(NCCCCCCCCCCC(N5CCN(CCCOC6=CC7=C(NC8=CC=C(F)C(Cl)=C8)N=CN=C7C=C6OC)CC5)=O)=O

Molecular Formula

C60H76ClFN10O8S

Molecular Weight

1151.82

References & Citations

[1]Yu X, et al. Exploring Degradation of Mutant and Wild-Type Epidermal Growth Factor Receptors Induced by Proteolysis-Targeting Chimeras. J Med Chem. 2022 Jun 23;65 (12) :8416-8443.