Pazopanib
Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.
Product Specifications
CAS Number
[444731-52-6]
Product Name Alternative
GW786034
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; c-Kit; FGFR; PDGFR; VEGFR
Type
Reference compound
Related Pathways
Autophagy; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Pazopanib.html
Purity
99.91
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(C1=CC(NC2=NC=CC(N(C3=CC4=NN(C(C)=C4C=C3)C)C)=N2)=CC=C1C)(N)=O
Molecular Formula
C21H23N7O2S
Molecular Weight
437.53
Precautions
H302, H315, H319, H335
References & Citations
[1]Harris PA, et al. Discovery of 5-[[4-[ (2,3-dimethyl-2H-indazol-6-yl) methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. J Med Chem. 2008, 51 (15), 4632-4640.|[2]Thakur A, et al. Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. Microvasc Res. 2011 Nov;82 (3) :346-50.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
PDGFRβ; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4
Citation 01
ACS Chem Biol. 2017 May 19;12 (5) :1245-1256.|Acta Pharmacol Sin. 2021 Jan;42 (1) :108-114.|Acta Pharmacol Sin. 2023 Jun;44 (6) :1135-1148.|Bioengineering (Basel) . 2025 Oct 19;12 (10) :1121.|Biomaterials. 2022 Oct:289:121800.|bioRxiv. 2024 Mar 12:2024.03.11.584490.|bioRxiv. 2025 Jul 12:2025.07.08.663754.|bioRxiv. 2025 Sep 21.|Cell Metab. 2021 Oct 5;33 (10) :2021-2039.e8.|Cell Physiol Biochem. 2016;38 (3) :926-38. |Cell Rep Med. 2025 Apr 2:102053.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Cell Syst. 2018 Apr 25;6 (4) :424-443.e7.|Exp Cell Res. 2020 Aug 1;393 (1) :112054.|Harvard Medical School LINCS LIBRARY|Hong Kong Polytechnic University. 2025.|Hum Cell. 2024 Dec 3;38 (1) :25.|J BUON. Jan-Feb 2020;25 (1) :464-471.|J Cell Sci. 2015 Sep 1;128 (17) :3317-29. |J Toxicol Sci. 2024;49 (8) :337-348.|Patent. US20210299273A1.|PLoS One. 2024 Nov 1;19 (11) :e0308647.|Sci Transl Med. 2018 Jul 18;10 (450) :eaaq1093.|Cell Signal. 2025 Nov:135:112054.
Available Sizes
Curated Selection
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