Mouse PD-L1 : Mouse PD-1 [Biotinylated] Inhibitor Screening ELISA Kit

Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.

Unopened kit should be stored at 2°C -8°C upon receiving. Find the expiration date on the outside packaging and do not use reagents past their expiration date. The opened kit should be stored per components table. The shelf life is 30 days from the date of opening.

This inhibitor screening ELISA kit is designed to facilitate the identification and characterization of new Mouse PD-L1 pathway inhibitors. The assay takes advantage of our in house-developed binding of biotinylated Mouse PD-1 to immobilized Mouse PD-L1 in a functional ELISA assay, and employs a simple colorimetric ELISA platform. Briefly, we provide you with a Mouse Biotinylated PD-1 protein, a Mouse PD-L1 protein, an anti-Mouse PD-L1 neutralizing antibody (as method verified Std.), and Streptavidin-HRP reagent.