Human IGFBP-1 Protein, His Tag (MALS verified)

IGFBP1 stands for insulin-like growth factor binding protein 1. It is a protein that binds to insulin-like growth factors (IGFs) and regulates their availability and activity within the body. IGFBP1 is part of a family of six IGFBPs (IGFBP1-6) that interact with IGFs to modulate their biological effects. IGFBP1 binds to IGFs (mostly IGF-1) with high affinity and prolongs their half-life in the circulation by protecting them from degradation. IGFBP1 has also been found to have IGF-independent functions, suggesting that it may have additional roles beyond regulating IGF signaling.

Product Specifications

Background

Specifications

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 27.2 kDa. The protein migrates as 32-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

P08833

Expression Region

Ala 26 - Asn 259

Host

HEK293

Target

IGFBP-1

Conjugation

Unconjugated

Tag

C-10xHis

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

90%

Bioactivity

Immobilized Human IGF-I, Fc Tag at 5 μg/mL (100 μL/well) can bind Human IGFBP-1 Protein, His Tag (Cat. No. IG1-H52H3) with a linear range of 0.01-0.156 μg/mL (QC tested).