PE-Labeled Human CLEC12A / MICL / CLL-1 Protein, His Tag (Site-specific conjugation)

PE-Labeled Human CLEC12A, His Tag (CLA-HP2Q3) is produced via site-specific conjugation of PE to Human CLEC12A, His Tag under optimal conditions with a proprietary technology. Human CLEC12A, His Tag is expressed from human 293 cells (HEK293) . It contains AA His 65 - Ala 265 (Accession # Q5QGZ9-2) .

Product Specifications

Background

CLEC12A (C-type lectin domain family 12 member A) is also known as CLL1, DCAL2, MICL. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. Evidence of distinct disease propagating stem cells in myelodysplastic syndrome (MDS) has emerged in recent years. The role of CLEC12A in MDS, however, remains to be elucidated. Furthermore, CLEC12A has been proposed as a promising marker of leukaemic stem cells in AML.

Specifications

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 27.3 kDa.

Accession Number

Q5QGZ9-2

Expression Region

His 65 - Ala 265

Host

HEK293

Target

CLEC12A

Conjugation

PE Labeled

Tag

N-10xHis

Source

Human

Applications

Evaluation of anti-CLEC12A CAR expression by flow cytometry. Please note that this product is NOT compatible to streptavidin detection system.

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.