APC-Labeled Human ROR1 Protein, His TagStar Staining

APC-Labeled Human ROR1 Protein, His Tag (RO1-HA2H4) is produced via conjugation of APC to Human ROR1 Protein, His Tag with a new generation site-specific technology under Star Staining labeling platform. Human ROR1 Protein, His Tag is expressed from human 293 cells (HEK293) . It contains AA Gln 30 - Glu 403 (Accession # Q01973-1) .

Product Specifications

Background

Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.

Specifications

This protein carries a polyhistidine tag at the C-terminus.

Accession Number

Q01973-1

Expression Region

Gln 30 - Glu 403

Host

HEK293

Target

ROR1

Conjugation

APC Labeled

Tag

C-10xHis

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.