Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Pentagalloylglucose

Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloylglucose inhibits UBE2T-mediated p53 ubiquitination, upregulates p53, downregulates RRM1/RRM2 in pancreatic cancer organoids. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities[1][2][3][4][5][6].

Product Specifications

CAS Number

14937-32-7

Product Name Alternative

Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; E1/E2/E3 Enzyme; JAK; Keap1-Nrf2; Reactive Oxygen Species (ROS) ; β-catenin

Type

Natural Products

Related Pathways

Apoptosis; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose.html

Purity

99.77

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(O)=C(O)C(O)=C1)O[C@@H]([C@@H]([C@@H](COC(C2=CC(O)=C(O)C(O)=C2)=O)O3)OC(C4=CC(O)=C(O)C(O)=C4)=O)[C@H]([C@@H]3OC(C5=CC(O)=C(O)C(O)=C5)=O)OC(C6=CC(O)=C(O)C(O)=C6)=O

Molecular Formula

C41H32O26

Molecular Weight

940.68

Precautions

H302, H315, H319, H335

References & Citations

[1]Zeng J, et al. Pentagalloylglucose disrupts the PALB2-BRCA2 interaction and potentiates tumor sensitivity to PARP inhibitor and radiotherapy. Cancer Lett. 2022 Oct 10;546:215851. |[2]Tong J, et al. Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells. J Pharmacol Sci. 2021 Dec;147 (4) :305-314. |[3]Fan CW, et al. Pentagalloylglucose suppresses the growth and migration of human nasopharyngeal cancer cells via the GSK3β/β-catenin pathway in vitro and in vivo. Phytomedicine. 2022 Jul 20;102:154192. |[4]Viswanatha GL, et al. Alleviation of transient global ischemia/reperfusion-induced brain injury in rats with 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose isolated from Mangifera indica. Eur J Pharmacol. 2013 Nov 15;720 (1-3) :286-93. |[5]Kim YH, et al. 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose increases a population of T regulatory cells and inhibits IgE production in ovalbumin-sensitized mice. Int Immunopharmacol. 2015 May;26 (1) :30-6. |[6]Jiang X, et al. Targeting UBE2T Potentiates Gemcitabine Efficacy in Pancreatic Cancer by Regulating Pyrimidine Metabolism and Replication Stress. Gastroenterology. 2023 Jun;164 (7) :1232-1247.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

MYOT Antibody (Center) Blocking Peptide
MBS9222394-01 0.5 mg

MYOT Antibody (Center) Blocking Peptide

Sign In for Pricing
View Details
MYOT Antibody (Center) Blocking Peptide
MBS9222394-02 5x 0.5 mg

MYOT Antibody (Center) Blocking Peptide

Sign In for Pricing
View Details
CXCL1 Antibody - middle region
OASG03232-100UL 100 µL

CXCL1 Antibody - middle region

Sign In for Pricing
View Details
Denosumab ELISA Kit
E55K0681 96 Tests

Denosumab ELISA Kit

Sign In for Pricing
View Details
Rabbit Anti CAT Polyclonal Affinity Purified (PBS with 0.05% sodium azide and 50% glycerol, pH7.4) (Western Blot,IHC,ELISA)
IRBAMLCATAP827120UL 1 Each

Rabbit Anti CAT Polyclonal Affinity Purified (PBS with 0.05% sodium azide and 50% glycerol, pH7.4) (Western Blot,IHC,ELISA)

Sign In for Pricing
View Details
Mouse Monoclonal HES6 Antibody (OTI1D6) - Azide and BSA Free
NBP2-72008 100 µg

Mouse Monoclonal HES6 Antibody (OTI1D6) - Azide and BSA Free

Sign In for Pricing
View Details