Imepitoin

Imepitoin (AWD 131-138) is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models.

Product Specifications

CAS Number

[188116-07-6]

Product Name Alternative

AWD 131-138

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/awd-131-138.html

Purity

99.87

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

O=C1N=C(N2CCOCC2)CN1C3=CC=C(Cl)C=C3

Molecular Formula

C13H14ClN3O2

Molecular Weight

279.72

Precautions

H302, H315, H319, H335

References & Citations

[1]Sigel E, et al. The antiepileptic drug AWD 131-138 stimulates different recombinant isoforms of the rat GABA (A) receptor through the benzodiazepine binding site. Neurosci Lett. 1998 Apr 3;245 (2) :85-8.|[2]Yasar S, et al. Evaluation of the novel antiepileptic drug, AWD 131-138, for benzodiazepine-like discriminative stimulus and reinforcing effects in squirrel monkeys. Eur J Pharmacol. 2003 Apr 4;465 (3) :257-65.|[3]Loscher W, et al. Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. Epilepsia. 2004 Oct;45 (10) :1228-39.